There has been a lot of video claims that is being
circulated around lately that anti-malarial drug already showing resistance to
malaria can now be used instead to treat deadly corona virus pandemic
This has caused death instead. Read here:
Do NOT use any drug that has not been tested or approved and
try it as a home remedy for SARS-CoV2
(Covid19).
It takes a minimum of 10 years for any drug to be approved after undergoing various phrases of
testing from lab studies to phrase 1, 2, 3 clinical trials followed continuously
by pharmacovigilance even approval and license has been given.
Granted chloroquine has already been well studied and evaluated
against malaria, and has long since been licensed and marketed as an antimalarial
drug.
We already know the pharmacodynamics of chloroquine on
malarial parasites by its inactivation of their cytochrome P450 2D6 (CYP2D6), the
dose, duration and the toxicity levels
This need not be studied again to shorten the time for chloroquine
to be used.
But we have completely no data on its mechanisms on the
coronavirus and the counter effects on the virus against the drug although some
have postulated, but those explanation do not seem plausible to me from my understanding in molecular
pharmacology
This needs to be studied and evaluated first in lab studies
and in multiple clinical trials before this therapeutic regimen can be safely
trusted
Even if chloroquine is effective, we do not know at what
dose to give it, and the duration to be given? We have no clue
Given at under dose, it may cause the corona virus to mutate
into a very virulent strain which the body immunological defense may no longer
be able to handle.
Given at high dose it can be fatal. The lethal dose for chloroquine
has been recorded at 4 – 5 g
Currently our own human immune system is being challenged by
this virus, and it is doing a very, very good job with many having recovered from
this infection on their own
Let our own immune system endowed to us by Nature to do this
job for us, and it is now doing this very effectively with very low mortality
ratio, increasing recovery rates compared to over 15 times the rate of new
infections.
This recovery ratios speaks volumes how Nature is currently doing
its job for us.
The corona virus is already been defied by our own immune
system, and in response, the virus too
is trying to fight back by its own genetic mutation into more hardier strain as
evidenced by the previous milder SARS CoV to the current more defiant Covid-19
strain
Take chloroquine as a
clear example how the Plasmodium spp (malarial parasites) mutated against this
antimalarial drug. Chloroquine is no more effective against malaria as much as
corona virus is going to mutate against it
But if we start to challenge it further with unapproved chloroquine
or its derivatives, what happens is the virus is being attacked by both sides –
our own immune system on one side - which
is already doing a very noble job for us, and the drug on the opposite side.
This is similar to the misuse of antibiotics causing
antibiotics resistant superbugs to emerge
This same scenario will surface with the present Covid-19 if
we challenge it with an under-dose of chloroquine.
Just do NOT put yourself between the Devil and the deep blue
sea with an agent yet to be evaluated by large-scale clinical trials before
approval.
The virus can undergo speciation by Natural Selection very
rapidly due to it very simple genomic chain (< 3,000 base) and they can turn
very, very nasty after that after being confronted
on both sides – one by our own immunological system and the other some drugs
for which we have no understanding its mode of action
We can see this very clearly with SARS CoV that changed into
Covid-19 after apparently lying very low for 16 years after being challenged by
our collective human immunological defenses passed on from person-to-person by
immune memory cells
If we have studied and understand evolutionary biology or
evolutionary medicine we see how life evolved so rapidly during the Cambrian
Radiation soon after the first RNA chemistry came into place followed by very
rapid changes in the mutation of DNA in the bacteria into higher species due to
very rapid environmental challenges 3,000 million years ago
Respect that observation.
It is purposely premeditated there by the Designer.
Respect Him (God) , and the virus He created, and do not try to be smarter than the
Designer by using unapproved chloroquine
as some home remedy to challenge a highly potential genetic mutation
We have already leant our lesson using all kinds of
antibiotics to fight bacterial infections causing the bacteria to mutate into
superbugs for which increasing generations of new anti-bacteria has no effect
Ignore Trump. He is
fickle-minded and keeps changing his words. He is a politician without any direction,
let alone any clue about evolutionary biology, virology, medicine or medical
sciences
Trust me with my down-to-earth layman explanation reachable
to all.
Hope this helps
Lim jb
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