Friday, May 29, 2026

Translating Medical Research into Clinical Practice

Nobel Prize in Medicine and Modern Trends in Medicine 

 

by:

 

lim ju boo, alias lin ru wu ( )


Clinicians (medical doctors)  have significantly fallen out of fashion for winning the Nobel Prize in Physiology or Medicine. While they once dominated the awards, the focus has shifted heavily toward basic molecular biology and genetics.

The Shift in Nobel Laureates

Historical trends highlight a massive divergence in who receives the prize

In the early 30 years (1901–1930), approximately 79% of the Medicine laureates were clinicians.  But now in the modern era that number has plummeted to just around 26%.

Why the shift? Today, societies from the academia, professional bodies, the public and the Nobel Committee are all more impressed by discoveries in medicine at molecular level rather than routine medical practice. Scientific societies and the now more educated  public too favors discoveries elucidating fundamental cellular, sub-cellular, and molecular mechanisms. Groundbreaking clinical applications often stem from this foundational biological research. There is also basic science bias among members of the public While thousands of clinicians save lives daily through direct translation of science, the prize heavily emphasizes "pure" discovery over day-to-day clinical utility and technique.

We need to look at the complexity of modern medicine. Progress in biomedical research such as genetics and biochemistry now largely takes place in controlled laboratory settings, which naturally elevates research scientists over active, hands-on medical practitioners.

Readers can learn more about how modern research intersects with clinical practice here:

 

https://www.nobelprize.org/can-clinicians-also-medical-research/

 

 

Nobel Prizes in Medicine: are clinicians out of fashion? here: 

 

https://journals.sagepub.com/doi/10.1258/jrsm.2011.110081

 

 Translating Medical Research into Clinical Practice here in Part 1

 

https://scientificlogic.blogspot.com/search?q=Translational+medicine+

 

Translating Medical Research into Medical Practice here in Part 2

 

https://scientificlogic.blogspot.com/2024/09/translational-medicine-bridging-gap.html

 

Translation into Mandarin

诺贝尔医学奖与现代医学发展趋势

通过:

林俊波,本名林如武(林 武)

临床医生(医学博士)在诺贝尔生理学或医学奖评选中已显著失宠。尽管他们曾长期主导该奖项的评选,但如今的关注焦点已大幅转向基础分子生物学与遗传学领域。

诺贝尔奖得主的变迁

历史趋势表明,获得该奖项的人群存在显著差异。

20世纪30年代初期(1901–1930年),约79%的医学诺贝尔奖得主为临床医生。然而在当今现代时期,这一比例已骤降至约26%

为何会发生这种转变?如今,学术界、专业组织、公众以及诺贝尔委员会都更青睐在分子层面取得的医学发现,而非常规的医疗实践。科学学会和如今受教育程度更高的公众也更倾向于那些阐明基本细胞、亚细胞及分子机制的发现。具有突破性的临床应用往往源于这些基础生物学研究。此外,公众成员中也存在对基础科学研究的偏好——尽管每天有数千名临床医生通过直接转化科学成果挽救生命,但该奖项却高度重视纯粹的发现,而非日常临床应用和技术。

我们需要审视现代医学的复杂性。遗传学和生物化学等生物医学研究的进展如今主要在受控的实验室环境中进行,这自然使科研人员的地位高于那些活跃在一线、亲力亲为的临床医生。

读者可在此处进一步了解现代研究与临床实践的交叉应用:

https://www.nobelprize.org/can-clinicians-also-medical-research/

诺贝尔医学奖:临床医生是否已过时?详见此处:

https://journals.sagepub.com/doi/10.1258/jrsm.2011.110081

将医学研究转化为临床实践(第一部分)

https://scientificlogic.blogspot.com/search?q=Translational+medicine+

将医学研究转化为临床实践(第二部分)

https://scientificlogic.blogspot.com/2024/09/translational-medicine-bridging-gap.html

 

 

Thursday, May 28, 2026

Defying Gravity with Two Fingers: The Physics and Biology Behind China’s Superhuman Stunt

The Hidden Masters of China and the Limits of  Human Anatomy : When Bones Learn to Become Steel

 

by:

 

lim ju boo - Chinese name - lin ru wu (( )

 

Two nights ago I was watching China CCTV 17 where they normally show agriculture in rural China.  Even  in the most rural areas of  China their agriculture is so advanced  that they are able to use high tech  technology to produce sufficient food not only to feed their massive population of 1.413 billion people (2026) - more than adequately and nutritionally, but they are even  able to  export their agricultural and food products  to other countries.  Their population is second only to India at 1.46 billion.  India officially overtook China as the world's most populous country in  April 2023. 

China has over 3,300 local, regional, and national TV channels. Of these, the vast majority are broadcast in Mandarin and local dialects. There are only 2 dedicated English-language television channels operated by the Chinese state broadcaster, namely, CGTN  and CGTN Documentary are in English. But here in Malaysia I can only receive 65 CCTV channels, and all are televised  in Mandarin.  


CCTV 17 is China's Agricultural and Rural Channel meant only for their domestic Chinese viewers which frequently also  showcases incredible regional talents, martial artists, and rural "hidden masters" is a masterclass in extreme physical conditioning. 

Among the countless the super-human stunts they do there, there was one I saw showing  a man 75 kg in weight lying forward using only his two last fingers  to support his massive body to do pumping exercises up and down. 


I was completely amazed. Being interested in physic and mathematics - besides other scientific fields - medicine and nutrition, I  started to calculate the forces exerted only on his two last fingers, and whether the massive forces applied would fracture his tiny fingers?

 Here’s the final result of my calculation.

For a 75 kg man performing a two-finger push-up (pump exercise), the total force exerted is approximately 735.75 newtons (N), and the pressure exerted on the fingertips is roughly 1,635,000 Pascals (Pa) or 237 psi.

 

Below are the details how I calculated it. 


First, Identify the Gravitational Force.

The total force exerted by the man's body is his weight  which is the product of his mass and the acceleration due to gravity (approx. 9.81m/ s2)

 

W = m x g

 

W = 75 kg x 0.81 m / s 2 = 735.75 newton (N)

This is the total force the ground must push back with to support him while he is off the ground.

The second step is to estimate the contact area (last two fingers)

Pressure is defined as force (F) divided by the area (A) over which it is applied:

 

P = F/A

 

 For this calculation, we assume each fingertip has a contact area of roughly =

 

2.25 cm 2  (1.5 cm x 1.5 cm)

 

Area per finger = 2.25 cm2  0.000225 m2

 

Total area for 2 fingers -  0.00045 m2

 

Third step is to calculate the pressure

 by using the pressure formula  which I presume everyone here knows and has learnt during their physics class in school

 

P = 735.75 newton (N) / 0.00045 m2  = 1,635,000 Pa (approximately)

 

The standard tire pressure units (psi) is approximately 237 psi. For comparison, this is about 7 times the pressure on his little fingers then  inside a typical car tire - simply amazing.


Final result is :

  

The force exerted is 735.75 newton (N), and the resulting pressure is approximately 1.64 million Pascals

The pressure of 1,635,000 Pa is equivalent to 16.14 standard atmospheres (atm), and the force is 735.75 newtons (N).


Atmospheric Pressure Equivalent:


The pressure on his  fingertips is equal to 16.14 atm.

1. One standard atmosphere equal 101,325 Pascals.

2. This is 16 times normal sea-level air pressure.

3. It equals the crushing pressure 150 meters underwater.

Force Equivalents

The total downward force remains 735.75 Newtons.

1. Equals 75 kilograms of force (kgf).

2. Equals 165 pounds of force (lbf).

3. Matches the gravitational weight of the entire body

For an untrained individual attempting this would almost certainly experience severe bone fractures and torn ligaments.  The calculated force and pressure push the human body right to the edge of its structural tolerances.

 Bio-mechanical data reveals exactly how the last two fingers (the ring and little fingers) handle these forces and why dynamic "pumping" makes the scenario incredibly dangerous.

Bone Fracture Limits (The Pinky vs. 735 N)

Human cadaver studies on finger crushing and jamming show that the structural limits of finger bones are highly dependent on alignment:


Pure Axial Loading (Perfect Alignment):

 

 Human finger bones (phalanges) are surprisingly strong when compressed straight down from the tip. Studies show it takes roughly 1,485 to 1,833 Newtons of pure axial force to fracture a pinky bone.


The Reality Check:


 Because our total calculated force is 735.75 N, the bones could theoretically support the weight statically, but only under absolute perfection. The moment the man pumps up and down, momentum adds dynamic shock loads that can easily double the force past the 1,500 N failure threshold. 

Ligament and Tendon Rupture (The Real Weak Point)

While the bones might survive a static hold, the ligaments and tendons are highly likely to tear during dynamic movement

Ligament and Tendon Rupture (The Real Weak Point)

While the bones might survive a static hold, the ligaments and tendons are highly likely to tear during dynamic movement

1. The Shear Force Threat: A push-up is not perfectly vertical. As the body moves up and down, the angle of the arm changes, translating the vertical force into lateral and hyper extension shear forces on the finger joints.

2. Collateral Ligaments: The collateral ligaments stabilizing the sides of the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints fail at much lower thresholds when subjected to twisting or bending.

3. Volar Plate & Extensor Tendon Tears: Under 735 N of hyper-extension force, the volar plate (the thick ligament preventing the finger from bending backward) or the extensor tendon would experience an avulsion rupture. The tendon would literally tear a piece of the bone away with it (a "Mallet Finger" or "bony pilon" fracture)

 

How Elite Athletes Defy This (Wolff's Law)


This brings me another thought.  I often wonder how Shaolin monks or elite martial artists manage to do two-finger push-ups without their hands exploding. They rely on a biological process called mechano transduction?


Wolff's Law of Bone Adaptation: 


When bones are subjected to progressive, sub-fracture stress over many years, they rebuild themselves to be denser and thicker. An elite practitioner's finger bones can become significantly thicker than an average person.


1.  Cortical Bone Denser Tuning: The outer layer of the phalanges adapts specifically to handle axial loads – evolution and adaptation during adverse conditions is something I can talk about confidently - I did my postdoctoral in evolution at Cambridge.  

2.  Ligament Hypertrophy: Connective tissues and tendons thicken gradually over a decade of training, raising their failure threshold well above the baseline 735 N requirement.

If an average, untrained 75 kg person tried this today, the combination of joint misalignment, lack of bone density, and sudden dynamic shock would cause immediate catastrophic structural failure of the hand.

When I  saw that stunt man performed this on CCTV 17 television, they are leveraging an extraordinary blend of lifelong biological adaptation, mechanical trickery, and specialized techniques to bypass the standard human breaking points. 


The "Claw" Geometry (Protecting the Joints)


As a former research medical scientist I normally pay hairline details to whatever I watch.  I closely watch the footage of masters performing these stunts on CCTV 17,  they almost never press down with perfectly straight, flat fingertips. Instead, they use a tightly locked "Claw" position (highly prominent in Shaolin One Finger Zen training).

1. No Hyperextension: By arching the fingers so the joints are bent slightly outward, they prevent the joint from collapsing or hyperextending backward.

2. Skeletal Stacking: This transfers the immense 735 N weight directly down the longitudinal axis of the bones. It bypasses the vulnerable ligaments and turns the finger into a rigid, bone-to-bone pillar.

Lifelong Bone Densification

Many of the individuals featured on CCTV 17 have practiced traditional conditioning methods since childhood. Decades of striking hard surfaces (like bags of rice, sand, and eventually iron filings) fundamentally rewrite their biology.

Micro-Fracture Healing:

Every time they train, they create microscopic fissures in the bone. The body overcompensates by filling these gaps with calcium, resulting in cortical bone thickening.

The "Iron" Result:

By adulthood, a practitioner's pinky and ring finger bones can possess a cross-sectional density vastly superior to an ordinary person's, easily raising their structural failure threshold well beyond the 1,500 N danger zone.

Biomechanical Leverage Illusions:

While the stunt looks like they are holding up 100% of their 75 kg body weight on their fingers, physics tells us they are using clever weight distribution:

1. The Pivot Point: In a standard push-up, the feet remain on the ground. The feet act as a fulcrum, bearing roughly 30% to 40% of the total body weight.

2. The Actual Load: This means the fingers are not actually bearing the full 735 N (75 kg). They are bearing closer to 440 to 515 N (45 to 52 kg). While still an extraordinary and dangerous amount of pressure for two small fingers, it drops the load safely below the absolute mechanical snapping point of a conditioned human bone.

3. CCTV's "Hidden Masters" Culture

China's CCTV networks heavily document these physical anomalies because they tie directly into historical martial arts culture. Practitioners like Xie Guizhong (who famously set a Guinness World Record on CCTV for performing 41 one-finger push-ups in 30 seconds) or Yuan Tingjun (who can statically suspend his body weight on two fingers) are genetic outliers who have combined elite calisthenics with ancient "Iron Body" conditioning.

It truly is a "superhuman" feat, not because they violate the laws of physics, but because they have spent a lifetime forcing their anatomy to adapt to them. We call this “ Darwinian medicine”.  Darwinian medicine (also known as evolutionary medicine combines evolution with medicine) applies the principles of evolutionary biology to understand why our bodies are vulnerable to disease. 


While conventional medicine asks how a disease works, Darwinian medicine asks why natural selection has left us susceptible to it something.  It is a branch of specialized medicine from  evolution.


There was also another one I saw among hundreds of these super-human stunts they do there every day. This one was a girl who somersaulted backwards exactly on the same spot 75 times within one minute. I shall write a comment separately on this one in my next article as this concerns physiology and medicine.


I am truly very impressed and amazed by all these people in China.


Sunday, May 24, 2026

Why Food and Nutrition May Become the Most Important University Courses of the Future (Part 2)

 


 Why Food and Nutrition May Become the Most Important University Courses of the Future 


By: Lim Ju Boo - lin ru wu ( ) 

On 20 May, I wrote an article on:  

The Most in Demand University Courses for The Future


https://scientificlogic.blogspot.com/2026/05/the-most-in-demand-university-courses.html

I promised I shall continue to write on this issue that concerns future generations of students to come. 

For generations, medicine has been regarded as one of the most prestigious and desirable university courses in the world. Parents proudly encourage their children to become doctors because medicine is associated with status, stable employment, respect and financial security. Students themselves often choose medicine believing that doctors will always remain highly demanded and better rewarded than graduates from most other disciplines.

However, over the years since the 1970's this is no longer true. Studying medicine today is no more lucrative as during my time. Why is this so? Read the reasons in the three links below later in order not be distracted here for the moment: 

1.  "Which area of healthcare is more important: "Nutrition or Medicine" 


 https://scientificlogic.blogspot.com/2024/03/which-area-in-health-care-is-most.html


2.  The Clinician vs Clinical Scientist vs Medical Scientist

 

https://scientificlogic.blogspot.com/search?q=too+many+clinics

 

3. Choosing a Right Course for a Career Pathway - Which One?

 

 https://scientificlogic.blogspot.com/2024/11/choosing-right-course-for-career.html

  

As a graduate in many disciplines of studies - from  medicine, nutrition, chemistry, zoology, physiology, food technology, and in food quality control across five  various universities that took me  nearly 18 years,  I have increasingly come to realize that the future needs of humanity may slowly shift in another direction, namely, towards food science, food technology and nutrition.

This is not because medicine is unimportant. Medicine will always remain a noble and essential profession. Humanity will always need doctors, surgeons and medical scientists to diagnose diseases, relieve suffering and save lives.

Yet when we calmly reflect upon the fundamental requirements of human existence, we begin to see that food and nutrition may ultimately become even more crucial for the long-term survival of civilization itself. I have emphasize this in my last write-up on:

The Most in Demand University Courses for The Future

Once again, every human being depends daily upon only three absolutely essential necessities for life:

1. Air

2. Water

3. Food

Without any one of these, life cannot continue.

Medicine, on the other hand, is not consumed daily by healthy individuals to sustain life. People take medicines mainly when they become ill. Even then, recovery still depends heavily upon adequate food and nutrition. A patient cannot survive on drugs alone without water, proteins, carbohydrates, vitamins, minerals and energy to nourish the body.

In reality, food itself is often the first and greatest medicine.

A starving child cannot recover merely from tablets or injections. A severely malnourished person cannot regain strength without nourishment. Even the best medications may fail when the body lacks the nutritional foundation required for healing and immunity.

At present, society may not fully appreciate the enormous importance of food science and nutrition because food is still relatively abundant in many countries. Supermarkets remain full, restaurants continue to operate and food supplies still appear secure.

But beneath this appearance of abundance lies a growing global challenge.

The world population continues to increase rapidly year after year. At the same time, agricultural land is steadily shrinking as forests and farmland are converted into housing estates, highways, factories, industrial zones and expanding cities. Climate change, droughts, floods, water shortages and environmental degradation increasingly threaten global food production systems.

Human civilization may one day discover that producing enough safe and nutritious food for billions of people is far more difficult than manufacturing medicines.

That future moment may become one of humanity’s greatest turning points.

When food shortages begin to emerge, the consequences are severe:

1. Hunger increases

2. Malnutrition spreads

3. Disease resistance weakens

4. Social unrest develops

5. Economic instability grows

6. Political tensions rise

7. Mortality increases

Under such circumstances, medicines alone cannot solve the problem because food itself becomes the primary medicine needed for survival.

History repeatedly shows that civilizations often collapse not only because of wars or diseases, but also because of famine and failure of food supplies.

Even today, whenever major disasters occur — whether earthquakes, floods, wars or droughts — what are the first emergency supplies sent to affected populations?

The priorities are almost always:

1. Food

2. Water

3. Shelter

4. Clothing

Only afterward come medicines and medical equipment.

This clearly demonstrates the true hierarchy of human survival needs.

Modern food and nutrition sciences are also no longer “minor” academic disciplines as many people once believed. These fields have evolved into highly sophisticated and rapidly expanding sciences involving:


1. Human nutrition 

2. Clinical nutrition

3.  Dietetics

4.  Food microbiology

5. Food biotechnology

6.  Food toxicology

7.  Food engineering

8. Food safety

9. Functional foods

10. Nutraceuticals

11. Public health nutrition

12. Agricultural technology

13. Sustainable food production

14. Molecular nutrition

15. Food legislation and regulation


Food safety itself has become one of the world’s greatest public health concerns. Contaminated food can affect entire populations within days. Problems involving food poisoning, microbial contamination, pesticides, heavy metals, antibiotic residues, toxic chemicals and microplastics have made food regulation increasingly important worldwide.

This explains why many national and international organizations place enormous emphasis upon food safety and food regulation.

In many disaster situations and humanitarian crises, food security becomes even more important than medical sophistication. A hungry population cannot remain stable regardless of how advanced its hospitals may be.

Furthermore, modern scientific research increasingly shows that many chronic diseases are strongly related to diet and lifestyle. Conditions such as obesity, hypertension, cardiovascular disease, Type 2 diabetes and certain cancers are often linked to nutritional habits.

Future healthcare may therefore focus increasingly upon prevention through nutrition rather than merely treating diseases after they develop.

In this sense, nutritionists and food scientists may become as important as doctors in safeguarding humanity’s health.

Historically, nutrition itself is actually a relatively young university discipline. Before the 1960s, very few universities offered formal undergraduate or postgraduate programs in nutrition. One of the pioneering institutions was Queen Elizabeth College under the University of London, where Professor Dr John Yudkin helped establish nutrition as an important academic field in the Western world. 

Professor John Yudkin, BSc (Lond), BA (Cambridge), MBBChir (Cambridge), MD (Cambridge), FRCP, FRIC, PhD (Cambridge), was a Professor of Physiology at the University of London from 1945 till 1954, and became a Professor of Nutrition at Queen Elizabeth College, University of London from 1954 till 1971.

He was a very eminent scientist -  a chemist, a biochemist, a clinician, a highly qualified physician with an FRCP and a higher postgraduate MD, a physiologist, and above all these professions he held, he was most well-known as a world most renown nutritionist. I was very fortunate to study directly under him as the first and only Malaysian  postgraduate student at that time in Queen Elizabeth College. It was he who cultivated my interest in clinical physiology and nutrition.  His knowledge in the clinical diagnosis of nutritional deficiency disease was first-class. 

 

Today, through his influence in nutrition and the prestige of the University of London, universities throughout the world — including those in Malaysia — offer extensive programs in food science, food technology, nutrition and dietetics. The rapid growth of these courses reflects the increasing global recognition that food and nutrition are fundamental sciences essential for humanity’s future survival.

Contrary to the misconception that food science and nutrition graduates have poor career prospects, graduates in these fields are now heavily involved in:

1. Food manufacturing industries

2. Pharmaceutical companies

3. Research institutions

4. Public health agencies

5. Hospitals

6. Universities

7. Food safety laboratories

8. Agricultural industries

9.Biotechnology companies

10. Nutritional product industries

11. Government regulatory authorities

12. International food organizations


In fact, many graduates in these disciplines are fully employed almost immediately after graduation because the global demand for food production, food safety and nutritional expertise continues to expand steadily. So far, I have not heard of any nutritionist unemployed. 

The food industry itself remains one of the largest economic sectors in the world. Every single day, billions of people purchase food to sustain themselves and their families. People visit food markets and grocery stores regularly, often daily or weekly. They do not visit hospitals or buy medicines every day unless they are ill.

Food therefore drives not only human survival, but also much of the global economy itself.

Perhaps future students and parents should begin to reconsider what careers may truly become most important in the coming decades.

The future world may not merely ask:
“How do we cure disease?”

It may increasingly ask:
“How do we feed humanity safely, nutritiously and sustainably?”

The student who studies food science, food technology or nutrition today may one day help prevent famine, improve global health, ensure food safety, strengthen food security and sustain millions of human lives.

That responsibility is no less noble than medicine. So we can clearly see the vast branches of nutrition and food sciences and each of them sub-divided into their specialized areas exactly just like in medicine. 

We can clearly see a student studying a 4-year general course in nutrition or in food science is not about "what food to eat, and what not to eat". It is a highly specialised technical area divided into so many branches with only some examples I have listed above. An undergraduate student in nutrition has to attend 8 hours of lectures a day in multi-disciplinary scientific and medical subjects including economics, sociology, human behaviour, statistics, epidemiology, including practical for 4 solid years before qualifying as a nutritionist.  Nutrition is not a 20 minutes talk about what to eat, and not what to eat. 

Indeed, as humanity faces growing population pressures and environmental challenges, food and nutrition may eventually emerge as among the most important university disciplines for the future survival of civilization itself. 

The practice of nutrition is a formal, regulated profession in Malaysia. Under the Allied Health Professions Act 2016 (Act 774). Nutritionists and dietitians are recognized health professionals, and practitioners must be formally registered with the Malaysian Allied Health Professions Council (MAHPC) to practice legally.


Translating Medical Research into Clinical Practice

Nobel Prize in Medicine and Modern Trends in Medicine    by:   lim ju boo, alias lin ru wu ( 林 如 武 ) Clinicians (medical doctors)  have si...