Dr.
Lawrence Ong, a former doctor colleague of mine in a WhatsApp chat was sharing
with us by asking me a question why must we all die? He sought my
comment why can't we live forever?
Thank you, Dr.
Lawrence, for sharing your interesting question soliciting my
views.
Let me handle
this question with care from all perspective I know - biological, social,
economics to spiritual.
Here are my
views - Why Must We Age and Die?
Title:
Biological
Necessity, Evolutionary Logic, and the Meaning of Mortality
Abstract
Aging and
death are often experienced as biological injustices and existential
tragedies, unwanted intrusions into conscious life. Yet when viewed
through the combined lenses of evolutionary biology, molecular science,
thermodynamics, and philosophy, aging reveals itself not as an error of nature,
but as an intrinsic consequence of how life itself is organized. Far from being
mere failures of repair, aging and death emerge as structural features of
living systems: products of genetic trade-offs, energetic limitations,
molecular imperfection, and the relentless arrow of time. Mortality, in this
deeper sense, is not simply the end of life, but one of the fundamental
conditions that make biological renewal, adaptation, and meaning possible.
First
Aging as an
Evolutionary Consequence, Not a Design Error
Natural
selection does not shape organisms for immortality. It shapes them for successful
reproduction within a finite world. Evolution “cares” about survival only
insofar as survival leads to the passing on of genes. Once reproduction has occurred,
the selective pressure to preserve the body indefinitely declines dramatically.
This explains
a profound asymmetry in biology: organisms are exquisitely robust in youth yet
increasingly fragile with age. Traits that cause harm only in later life are
weakly opposed by evolution, because their effects fall outside the critical
window of reproduction. Aging, therefore, is not directly selected
for, but it is permitted. And in evolution, what is permitted
becomes inevitable.
In this sense,
aging is not a design flaw. It is a tolerated consequence of a system optimized
for reproduction rather than permanence.
Second
Genetic
Trade-offs: The Price of Early Success
Life is built
on compromise. Many of the same genes that confer strength, fertility, and
resilience in youth carry hidden costs that manifest only later. This
principle, known as antagonistic pleiotropy, reveals a central truth:
biological traits are rarely purely beneficial. They are negotiated settlements
between immediate survival and long-term deterioration.
The very pathways
that stimulate growth and cell division in early life increase the risk of
cancer in old age. Inflammation that protects against infection in youth
becomes the seed of chronic disease later. These are not biological
mistakes; they are the price paid for early success.
Closely
related is the disposable soma theory, which proposes that organisms
possess limited energy. Evolution consistently favors investing this energy in
reproduction rather than in perfect cellular maintenance. The body, therefore,
is not engineered for eternity. It is engineered to last long enough.
Third
Cellular Aging
and the Accumulation of Damage
At the deepest
level, aging is the slow triumph of damage over repair.
Each time a
cell divides, its telomeres, the protective caps at the ends of
chromosomes shorten. When they reach a critical length, the cell can no
longer divide and enters senescence or programmed death. This protects against
cancer yet contributes inexorably to tissue aging.
Meanwhile,
normal metabolism continuously generates free radicals, those highly
reactive molecules produced especially within mitochondria during energy
production. These molecules are not foreign enemies; they are unavoidable
by-products of being alive.
Over time,
free radicals damage DNA, proteins, and lipid membranes. Mitochondrial DNA,
poorly protected and highly exposed, accumulates mutations, reducing energy
production and generating even more free radicals in a vicious cycle. The cell
slowly becomes less efficient, more unstable, and more inflammatory.
Aging,
therefore, is not caused by a single mechanism. It is the cumulative effect of
countless microscopic imperfections, magnified relentlessly by time.
Even our best
repair systems operate under the constraints of thermodynamics. Absolute
fidelity is physically impossible. Life can delay entropy, but it cannot
defeat it.
Fourth
Why Evolution
Requires Not Only the Young, but the New
It is tempting
to imagine that if organisms could remain youthful indefinitely, evolution
would still proceed. But this is a misconception.
Evolution
depends not merely on survival, but on generational turnover. Each new
generation introduces novel genetic combinations, new solutions tested
against changing environments, emerging pathogens, and shifting ecosystems.
If older
individuals dominated indefinitely, even in perfect health, they would
genetically anchor the species to past conditions. Innovation would slow.
Adaptation would weaken. Immortality, paradoxically, would make life more
fragile, not more resilient.
Death does not
merely make room for the young. It makes room for the new.
Fifth
Ecological and
Population Constraints
Life unfolds
within finite ecosystems. Resources are limited. Mortality regulates population
size and prevents ecological collapse.
Without aging
and death, competition would intensify endlessly. Younger individuals would be
denied opportunities to mature and reproduce. Social and biological systems
would lose balance and resilience.
In this sense,
death is not merely an individual event. It is a population-level
stabilizer, an ecological necessity.
Sixth
Entropy and
the Arrow of Time
From a
physical standpoint, aging reflects the second law of thermodynamics. All
ordered systems require constant energy input to resist disorder. Living
organisms are extraordinarily ordered systems, perpetually fighting entropy.
Yet entropy
always wins in the long run.
Aging is
simply the biological expression of the arrow of time. Immortality would
require perfect error correction in a universe where perfection is forbidden by
physical law. Thus, aging is not merely biological, it is cosmological.
Seventh
Mortality,
Suffering, and the Human Condition
Beyond
molecules and genes lies the human experience.
Aging brings not
only biological decline, but social, psychological, and economic challenges:
chronic disease, frailty, sensory loss, cognitive decline, loneliness,
financial insecurity, and social invisibility. These are not abstract concepts;
they are lived realities.
And here we
arrive at the deepest question:
Should we seek
to abolish aging altogether?
To fully
“medicalize” aging, to treat it solely as a disease to be
cured, risks erasing a fundamental dimension of what it means to be human.
While extending healthy life is a noble goal, the pursuit of absolute longevity
raises profound ethical dilemmas.
An
indefinitely extended lifespan would reshape society in troubling ways:
fewer young people, slower turnover of leadership, concentration of power in
increasingly older generations, and diminished space for new minds, new genes,
and new ideas.
It may be that
what benefits the individual conflicts with what sustains the species.
In this light,
the death of the individual may be biologically necessary for the health of
humanity itself.
For instance,
South Korean doctors and medical students began a massive, prolonged walkout
in February 2024 to protest the government’s plan to significantly
increase the number of medical school admissions. As of February 2026, the
initial 18-month strike (February 2024–late 2025) has officially ended, but the
conflict is ongoing with new, slightly modified proposals, and the medical
community remains heavily critical.
Various reasons were given by the doctors why they disagree with their government proposal to train more younger doctors – but we shall not go into them. But I think this would be a disadvantage to the whole country and to the older doctors too when they too must grow old and die. Without younger and more creative doctors to replace them, the whole future generations of Koreans who need health care will suffer. But they are medical doctors - tens of thousands of them on long-hauled strike throughout their country. Though they are doctors they cannot think with wisdom the consequences of their action on their society, except their own field of medicine. In biological evolution we label this as self-preservation, and selfishness, not altruism
Aging and
death arise from the very forces that make life possible: evolution, energy
limitation, molecular imperfection, entropy, and environmental changes. They
are not arbitrary punishment, nor signs of biological incompetence. They are
the cost of adaptability, diversity, and progress.
Evolution does
not invest in eternal individuals.
It invests in enduring lineages.
Not in permanence, but in renewal.
Seen this way,
aging and death are not merely endings.
They are the hidden mechanisms by which life continues.
Or, to put it
more gently:
We do not die
because life has failed.
We die because life must move forward.
And perhaps
that, dear readers, is the deepest and most humbling truth of
all.
By the way the
oldest person that ever lived was Jeanne Calment of France who was born on
February 21, 1875, and died on August 4, 1997, at the age of 122 years and 164
days, other than Methuselah as the oldest person mentioned in the Bible,
reported to have lived to the age of 969. According to the Book of Genesis, he
was the son of Enoch, grandfather of Noah, and died just before the great
flood.
Despite their
exceptional longevity, they too finally died.
See also this
slide presentation here:
https://scientificlogic.blogspot.com/2024/04/reasons-for
or-life-spans.html
See also
here
https://scientificlogic.blogspot.com/2024/04/reasons-for-life-spans.html?m=1
For Further
Reading
1. Medawar,
P. B. An Unsolved Problem of Biology. H.K. Lewis, 1952.
2. Williams,
G. C. “Pleiotropy, Natural Selection, and the Evolution of Senescence.” Evolution,
1957.
3. Kirkwood,
T. B. L. “Evolution of Aging.” Nature, 1977.
4. López-Otín,
C. et al. “The Hallmarks of Aging.” Cell, 2013.
5. Harman,
D. “The Free Radical Theory of Aging.” Journal of Gerontology,
1956.
6. Rose,
M. R. Evolutionary Biology of Aging. Oxford University Press, 1991.
7. Asimov,
I. “The Immortal Bard” and essays on biology and time, various collections.
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