Tuesday, December 31, 2024

My Humble Greetings for the New Year 2025

 

Hi everyone,

As we bid farewell to 2024, let’s take a moment to reflect. How was the year for you? Did it bring triumphs, challenges, or simply the calmness of another chapter lived?

For me and my wife, 2024 was a year of simplicity and gratitude. Our total expenditure for the year was RM 42,141.14—an average of RM 3,511.76 per month. With that, we lived comfortably, carrying no burdens of unnecessary materialism. Some might wonder how. The answer lies in embracing a life guided by humility, wisdom, and spiritual contentment.

From my university days, I learned to value life not by its luxuries but by the richness of experiences and the truths imparted by mentors. Even during my postgraduate years in England, I viewed my scholarships not as mere financial aid but as a form of sustenance to support my learning. My “job” was simple: absorb knowledge shared by brilliant professors and return those truths during exams. It was a humble journey, but one that fulfilled both my needs and my soul.

As human beings, we often forget that our time on Earth is fleeting—a tiny speck in a vast universe spanning 93 billion light-years and housing uncountable worlds. And yet, we chase after material possessions, believing they will bring us happiness or permanence.

But let’s pause and consider: What do we truly need to live a meaningful life? The answer is surprisingly simple:

  1. Air to breathe – A gift from God, free for all.
  2. Water – For drinking, cleansing, and sustaining life.
  3. Simple food – To nourish our bodies.
  4. Shelter – A small, safe space to rest and rejuvenate.
  5. Clothing – For protection and dignity.
  6. A mind to reason – A priceless tool for reflection and growth.
  7. A soul given by God – The eternal essence that transcends our physical existence.

Everything else—whether it’s the latest gadgets, luxury items, or excessive possessions—merely adds weight to our lives, burdens that cannot follow us into the grave.

In 2024, we said goodbye to many notable figures—individuals who once held wealth, power, and fame. Their journeys remind us of a profound truth: when we leave this world, we take nothing with us except the state of our soul.

Consider the recent Jeju Air disaster, where 179 lives were lost in an instant. It’s a stark reminder of how unpredictable life is. In the end, it’s not the material things we’ve gathered that matter, but the legacy we leave behind—the love we’ve shared, the kindness we’ve shown, and the wisdom we’ve imparted.

As we step into 2025, let us live wisely, embrace simplicity, and cherish the gifts that truly matter. Let’s count our days not in terms of material gains but in moments of joy, gratitude, and purpose.

“So teach us to number our days, that we may apply our hearts unto wisdom” (Psalm 90:12).
“For what shall it profit a man, if he shall gain the whole world, and lose his own soul?” (Mark 8:36).

Wishing you all a New Year filled with peace, purpose, and the wisdom to live meaningfully. Let us journey through 2025 with lighter hearts, free from unnecessary burdens, and richer in spirit.

Warm regards,
jb lim

An Endless Energy from A Diamond Battery?


It is just past midnight on January 1, the Year 2025. Before I write let me wish every reader

A  very blessed and bountiful New Year 

An inquirer sent me a Tik Tok about a “diamond battery” that never runs out of energy. She asked me if this is true? The link is here:

https://www.tiktok.com/@graceistruth2012/video/7446336612054732064

This battery uses isotope of carbon 14 as the source of energy.

Instead of merely  answering her yes or no, I thought I should write an article on this where I can explain in greater technical details and expand on this, than what this gentleman in the Tik Tok claims.  

 From what I know many years ago, diamond battery is the name of a nuclear battery concept proposed by the University of Bristol Cabot Institute during its annual lecture held on 25 November 2016 at the Wills Memorial Building. This battery is proposed to run on radioactivity from waste graphite blocks (previously used as neutron moderator material in graphite-moderated reactors) that would generate small amounts of electricity for thousands of years. The battery is a beta voltaic cell using carbon-14 (14C) in the form of diamond-like carbon (DLC) as the beta radiation source, and additional normal-carbon DLC to make the necessary semiconductor junction and encapsulate the carbon-14.

The estimated power of a small C-14 cell is 15 Joules / day for thousands of years. 

(For reference, an AA battery of the same size has about 10 kilojoules total, which is equivalent to 15 J / day for just 2 years). 

The proposer who suggested this idea noted it is not possible to directly replace an AA battery with this technology, because an AA battery can produce bursts of much higher power as well. Instead, the diamond battery is aimed at applications where a low discharge rate over a long period of time is required, such as space exploration, medical devices, seabed communications, microelectronics, etc.

The diamond battery emits energy, but only as small doses of radioactivity that may last for thousands of years as it slowly decays. Let me expand on this further. 

What I know about this diamond battery is, it is a type of beta-voltaic cell, meaning it converts beta radiation (high-energy electrons) emitted during radioactive decay into electricity. It utilizes carbon-14 (C-14), a radioactive isotope commonly found in graphite blocks used in nuclear reactors, as the radiation source.

A diamond-like carbon structure encapsulates the radioactive material, acting both as the radiation source and as a semiconductor.

Characteristics and limitations of this battery is that the power output of such batteries is extremely low, in the order of 15 Joules/day for a small C-14 cell. This makes it unsuitable for high-power devices but ideal for long-lasting, low-power applications such as pacemakers, satellites, or deep-sea sensors. The diamond structure encapsulating the C-14 is designed to block almost all radiation, making it safe for use in various applications.

How long can this battery last? The half-life of carbon-14 is approximately 5,730 years. This means the radioactivity—and thus the energy output—will decrease by half every 5,730 years. While this is exceptionally long compared to conventional batteries, the power output is small and continuous. Carbon-14 cannot undergo fission like uranium or plutonium. Fission occurs in very heavy nuclei (like uranium-235 or plutonium-239) that can split into smaller nuclei upon absorbing a neutron, releasing large amounts of energy. 

Carbon-14 undergoes beta decay, a much slower process where a neutron in the nucleus converts into a proton, releasing a beta particle (electron) and an antineutrino. This decay process is not capable of producing the immense energy as seen in nuclear fission. On feasibility and applications, the diamond battery is not a solution for high-power needs, its long lifespan makes it an attractive option for applications where energy density (long duration) is more critical than power density (high bursts of energy).

Some possible applications include space exploration.  Powering sensors or devices on distant planets or in deep space where replacing batteries is impractical.

It has its use in medical devices since long-term implants like pacemakers require minimal maintenance. It can be used for remote systems such as  seabed sensors or remote communication relays.

Claims on platforms like TikTok and videos often exaggerate or oversimplify scientific concepts. While the diamond battery does "last thousands of years," its power output is minuscule and not suitable for most everyday applications. It is not a perpetual energy source and certainly not a competitor to fission reactors or chemical batteries in terms of power.

Thus, my answer and opinion of that claim is that the diamond battery is an ingenious concept for specific use cases, particularly in extreme or remote environments. However, it is not a revolutionary power source that can replace conventional batteries or nuclear power in broader applications. Its role is more niche, complementing existing technologies rather than replacing them.

In fact, carbon-14 is not used for this purpose. It is used for radiocarbon dating. It  is a radiometric dating method to determine the age of carbonaceous materials up to about 60,000 years old. The technique was developed by Willard Libby and his colleagues in 1949 during his tenure as a professor at the University of Chicago. Libby estimated that the radioactivity of exchangeable 14C would be about 14 decays per minute (dpm) per gram of carbon, and this is still used as the activity of the modern radiocarbon standard. In 1960, Libby was awarded the Nobel Prize in chemistry for this work.

One of the frequent uses of the technique is to date organic remains from archaeological sites. Plants fix atmospheric carbon during photosynthesis; so, the level of carbon-14 (C-14) in plants and animals when they die, roughly equals the level of C-14 in the atmosphere at that time. However, it thereafter decreases exponentially; so, the date of death or fixation can be estimated. The initial C-14 level for the calculation can either be estimated, or else directly compared with known year-by-year data from tree-ring data (dendrochronology) up to 10,000 years ago (using overlapping data from live and dead trees in a given area), or else from cave deposits (speleothems), back to about 45,000 years before present. C-14 is used by scientists to date fossil remains in the evolution of life on Earth - an area I have some idea. 

Carbon-14 is also produced in the upper troposphere and the stratosphere by thermal neutrons absorbed by nitrogen atoms. When cosmic rays enter the atmosphere, they undergo various transformations, including the production of neutrons.  In all,  this natural process as carbon 14 decays it does emit very tiny amounts of energy over thousands of years. In fact, all radioactive substances, not just carbon -14, emit tiny amounts of radioactivity, that is also a form of energy.

Let me explain radiocarbon dating we use in biological evolution just a little bit more. The fact that plants and animals maintain a balance of carbon-14 while alive—and that this balance starts to decrease after death—is a cornerstone of archaeology, palaeontology, and geology.

Willard Libby's pioneering work in 1949 revolutionized how we understand historical timelines, allowing us to date organic remains up to 60,000 years old. The correlation with tree rings (dendrochronology) and other data further validates the method, making it one of the most reliable tools in radiometric dating. Production of carbon-14 is also found in the atmosphere. The natural formation of carbon-14, via cosmic rays interacting with nitrogen-14, is a fascinating process. These cosmic rays generate high-energy neutrons, which are absorbed by nitrogen nuclei, producing carbon-14 in this reaction:

 

714N+n→614C+11H

 

This means that carbon-14 is continually replenished in the atmosphere, maintaining a near-steady-state equilibrium of radioactive carbon in the biosphere, at least on short geological timescales.

As carbon-14 undergoes beta decay, it emits tiny amounts of energy in the form of beta particles (high-energy electrons) and antineutrinos. These emissions are the very basis of its use in diamond batteries and also why it is detectable in radiocarbon dating.

The decay equation is:

614C→714N+β−+νˉe

 

The energy emitted during beta decay is relatively small—on the order of 0.156 MeV (million electron volts) per decay. For context, nuclear fission (as in uranium-235) releases 200 MeV per fission event, which is why carbon-14 does not produce the vast energy we associate with nuclear reactors.

Every radioactive isotope emits energy as it decays. The form of radiation depends on the type of decay. Alpha decay releases helium nuclei (alpha particles). Beta decay emits electrons or positrons (beta particles) and neutrinos, whereas gamma decay emits high-energy photons (gamma rays).

The energy released by these processes is indeed a form of energy, but it varies greatly between isotopes. For example, carbon-14 emits low-energy beta particles, uranium-238 releases higher-energy alpha particles while cobalt-60 emits strong gamma rays used in medical therapies.

However, in most cases, the energy output is modest and spread out over long periods, unless we are dealing with highly enriched materials (like those in nuclear reactors).

Indeed, the very same principle underpins technologies ranging from nuclear batteries to radiometric dating and even radiotherapy. What differs is how the energy is harnessed.

In the case of carbon-14, the energy is minuscule but steady, making it useful for niche applications requiring longevity rather than power density. Other isotopes, like uranium-235 or plutonium-239, are chosen for applications demanding concentrated energy release.

However, if we want quick release of large amounts of energy then we should look for nuclear material like uranium, plutonium, and thorium where its proton and neutron can be split apart as fissionable material after its ore is purified into enriched uranium (U-235), uranium-233, and plutonium-239. Uranium ore concentrates are considered to be a "source material"

If the goal is to achieve a quick and concentrated release of energy, fissionable materials such as enriched uranium (U-235), uranium-233, or plutonium-239 are the go-to choices. Let me expand slightly on this for clarity and depth:

Fissionable materials like uranium, plutonium, and thorium are capable of undergoing nuclear fission—the splitting of their nuclei into smaller fragments—when struck by a neutron. This process releases an enormous amount of energy in the form of heat and radiation.

Key fissionable isotopes are uranium-235 (U-235). This is found naturally in uranium ore, but only 0.7% of uranium is U-235. Enrichment is required to increase its concentration for use in reactors or weapons. Enrichment is critical for sustained chain reactions.

Plutonium-239 (Pu-239) is another fissile material. Synthetic isotope produced by irradiating uranium-238 in reactors is highly fissile and used in nuclear weapons and fast reactors.

Uranium-233 (U-233) is produced from thorium-232 via neutron capture in thorium reactors. It offers a potential alternative to uranium or plutonium in the future.

The Role of Enrichment and Purification:

Raw uranium ore or thorium ore cannot directly be used as fuel. It must undergo extensive purification and sometimes enrichment to isolate or increase the percentage of fissile isotopes.

Enriched uranium contains a higher percentage of U-235 (e.g., 3-5% for reactors, 90%+ for weapons). Plutonium-239 is separated chemically after being bred in reactors.

These purified materials are termed "special nuclear materials" due to their ability to sustain a chain reaction.

Chain Reactions and Energy Release:

The power of fission lies in the chain reaction, where each fission event releases energy (~200 MeV per fission). Neutrons which induce further fission in nearby nuclei becomes a cascading process resulting in an explosive release of energy used in nuclear weapons or a controlled release in nuclear reactors.

For example:

922/35U+n→56/141Ba+36/92Kr+3n+Energy

The released energy comes from the conversion of mass into energy, as described by Einstein’s famous equation:

E=mc2

Source Materials vs. Special Nuclear Materials:

Uranium ore concentrates are considered "source material. “They are  naturally occurring materials like uranium ore or thorium ore. These are then purified as special nuclear materials. The purified or enriched isotopes like U-235, U-233, and Pu-239 are the ones that can sustain chain reactions.

Source materials are less reactive and pose a lower proliferation risk, while special nuclear materials are tightly controlled due to their potential for use in weapons.

Energy Density Comparison:

It’s worth noting that the energy density of fissionable materials far exceeds that of chemical fuels. Fission of 1 kg of U-235 releases ~80 terajoules of energy, equivalent to burning ~3,000 tons of coal! This is why fissionable isotopes are the backbone of nuclear energy and weapons.

Materials like uranium, plutonium, and thorium are sought after for large-scale energy production.

However, if we  want much cleaner and more long-lasting energy we might as well source them from the Sun by fusing hydrogen nuclei into helium that could last us at least for another 5 billion years. But I don't think we can do this on Earth as this would require immense pressure to squeeze the hydrogen together like those gravitational forces in the Sun and stars.

Many years ago, I  read that Chinese scientists have managed to create an artificial  'sun' but only for a few seconds. Here on Earth, any fusion reaction will have to take place at a tiny fraction of the scale of the Sun, without the benefit of its gravity. So, to force hydrogen nuclei together on Earth, engineers need to build the reactor to withstand temperatures at least ten times that of the Sun – which means hundreds of millions of degrees. But my feeling is, in practice we need to pump in more energy to squeeze the hydrogen nuclei together than we can get out of it. In  actual practice, we can't get something more than we put in, can we?

Fusion Energy: The Power of the Stars

Fusion, the process that powers the Sun and stars, involves combining hydrogen nuclei (protons) to form helium, releasing enormous amounts of energy in the process. The reaction primarily responsible in the Sun is:

4H→4He+2e++2νe+Energy

On Earth, we aim to fuse deuterium and tritium (isotopes of hydrogen) because they require slightly less extreme conditions and release more energy per reaction:

2H+3H→4He+n+17.6MeV

The question we ask is, why is fusion ideal for clean energy? Fusion has enormous potential. First, there is an abundant fuel supply. Deuterium can be extracted from seawater, and tritium can be bred from lithium. There is also minimal waste in that fusion does not produce long-lived radioactive waste like fission. There is also no risk of meltdown. Fusion reactors inherently shut down if containment is lost, unlike fission reactors.

It virtually has unlimited energy. If harnessed successfully, fusion could meet humanity’s energy needs for millennia.

But there is a catch. It needs extreme conditions. The Sun relies on gravitational confinement, with its immense pressure and temperature (~15 million °C) to overcome the Coulomb barrier (the electrostatic repulsion between positively charged nuclei).

On Earth, we cannot rely on our  gravity, unlike those crushing gravities found in the Sun and stars. So, instead of gravity, we must create even higher temperatures—hundreds of millions of degrees—to provide the nuclei with enough kinetic energy to overcome this barrier.

Energy Input vs. Output:

The energy required to heat and contain the plasma is currently greater than the energy released by the fusion reaction. We cannot yet get out more energy than we put in. The Lawson Criterion defines the conditions (density, temperature, and confinement time) needed for a net energy gain. Meeting this criterion is the central challenge.

There is also the problem with the containment of plasma. At such high temperatures, hydrogen exists as a plasma (a soup of ions and electrons). Containing this plasma without it touching and destroying the reactor walls is a monumental task.

There are two primary approaches to confinement. These are, magnetic confinement (e.g., Tokamaks): Using powerful magnetic fields to hold the plasma in a donut-shaped reactor.

Inertial confinement (e.g., Laser Fusion) by compressing and heating small fuel pellets with intense laser pulses.

Achievements in Fusion: The 'Artificial Sun'

China and other countries have indeed made impressive strides. For example, China’s EAST Tokamak (Experimental Advanced Superconducting Tokamak)  In 2021, it maintained a plasma temperature of 120 million °C for over 100 seconds, setting a record.

International Thermonuclear Experimental Reactor (ITER) is a massive collaborative project aiming to achieve a net energy gain by the 2030s.

While these experiments are remarkable, they are still in the proof-of-concept phase. Sustaining a stable, net-positive energy reaction remains the goal.

Net Energy Gain and Recent Progress:

In December 2022, researchers at the National Ignition Facility (NIF) in the United States achieved a historic milestone. For the first time, a fusion experiment produced more energy than was absorbed by the fuel (a small net gain). However, when considering the total energy input (e.g., energy required to power the lasers), the process was still far from breakeven.

This shows progress but underscores the immense engineering challenges that remain.

Can We Get More Energy Out Than We Put In?

Theoretically, yes! Fusion has the potential for a high energy yield because of the mass-to-energy conversion described by Einstein’s equation (E = mc^2).

The key is to overcome the engineering hurdles by improving plasma confinement, reducing energy losses, and scaling the technology for practical use.

If these challenges are solved, fusion could deliver vast amounts of energy with a fuel efficiency far exceeding any current technology.

Closing Thoughts:

While fusion presents extraordinary promise, it is not yet practical because the energy input still exceeds the output in most experiments. However, the continued global investment and breakthroughs suggest that fusion could become a reality within the next few decades.

Fusion is indeed the "holy grail" of energy—a clean, sustainable source that mimics the very process powering the stars. If humanity succeeds in harnessing it, we could secure a virtually limitless energy future.

However, if the present and future humanity wants an endless source of energy beyond his needs here’s another source I have thought about and have penned on Monday, September 4, 2023, here:

An Unending Source of Energy from The Ocean

1.      Scientific Logic: An Unending Source of Energy from The Ocean

2.      https://scientificlogic.blogspot.com/2023/09/an-unending-source-of-energy-from-ocean.html

This is astronomically far, far, far more fantastic in energy output to meet the entire humanity's energy needs for almost all eternity than that “diamond battery” the gentleman in the Tik Tok claimed which led the inquirer asked me about …who  in turn led me to write this article to celebrate my brand New Year 2025 for academic fun.

-  ju-boo lim 

 

Saturday, December 28, 2024

We are Only on Transit here in This World to The Next World

 

The origin of life  and astrobiology were  presented  at numerous technical forums.

However, I have another personal theory on the origin of life on Earth different from those offered by other scientists elsewhere. 

Astronomers and scientists tell us we are made from stardust. When massive stars explode as a supernova many of the elements of the periodic table, including those that make up the human body are released into space. These elements such as hydrogen, oxygen, nitrogen and phosphorus that make up the composition and DNA of the human body finally arrived on earth some 4.5 billion years ago to make up the soil on Earth.

Whatever the scientists claim, as far as I am concerned, none of these elements in the dust were alive till God blew the breath of life into for them to become a living soul as

In short, the origin of life may have started in another world of a massive star, and their elements brought to earth from a supernova explosion to begin a new life here in our world. Since life is the breath of God that cannot die or be destroyed, except the physical body containing these elements of life, the soul of life will be released. The breath of God becomes the soul of our body. It then goes in transit to another world after the death of the physical body here in this world  to begin another life in another world. This becomes an endless cycle of life from one world to the next.

Here I offer a profound fusion of scientific understanding and theological perspective, which beautifully integrates the origin of life and the essence of the soul. Let me expand my  thoughts.

The Stardust Connection and the Formation of Life:

Scientists believe the elements that make up our bodies—carbon, hydrogen, oxygen, nitrogen, phosphorus, and others—originated in the nuclear furnaces of stars and were scattered across the universe in supernova explosions. This "stardust" eventually coalesced to form planets, including Earth. This view, rooted in astrophysics, provides a humbling perspective: all life on Earth is inherently connected to the cosmos.

However, these elements are not inherently "alive." Life requires more than just the presence of organic or inorganic molecules. In science, the transition from non-life to life remains one of the biggest mysteries, often referred to as the study of abiogenesis. The reference to Genesis 2:7—where God breathes life into Adam tell us  that life requires an animating force or principle beyond physical components.

Life as the Breath of God:

The idea that the "breath of God" (or the divine spark) is what animates lifeless matter is deeply meaningful. In this framework, life is not merely biochemical activity but something sacred and eternal. The breath of life transforming matter into a living soul is also the same with many spiritual beliefs that life is more than its physical manifestation.

From a scientific perspective, one could interpret this "breath" as the emergence of consciousness, self-awareness, or the inexplicable spark that distinguishes living organisms from non-living matter. Biologically, even though life is a product of intricate chemical reactions, its origin and the essence of consciousness remain beyond the full grasp of science.

An Endless Cycle of Life Across Worlds:

I have always thought life transitioning from one world to another through the breath of God is something most people may not have thought possible. It has similarities with some concepts in both spiritual traditions and modern scientific theories:

Spiritual Viewpoint:

Many religions speak of life as a journey or cycle. Hinduism and Buddhism describe reincarnation, where the soul continues its existence in a new form. Christianity views the soul as eternal, destined for a new phase of existence after physical death.

Chinese Traditions:

In Hokkien and Hainanese, "qui sing" (去世) and "qui tin" (归天) describe death as a soul passing or returning to the heavens

Similarly, in classical Chinese philosophy, influenced by Daoism, death is often seen as a return to the Dao (), the eternal source of all existence.

In Hinduism:

Death is described as a journey of the soul (Atman) leaving the physical body and continuing its path through reincarnation (samsara). It is believed the soul transitions from one body to another until it achieves moksha, or liberation from the cycle of life and death.

The term "Mahasamadhi" refers to a yogi's conscious departure from their body, emphasizing this as a spiritual passage.

Buddhism:

Buddhism describes death is seen as a transition in the cycle of rebirth (samsara). The Tibetan Book of the Dead (Bardo Thodol) describes the "bardo," or intermediate state, where the soul moves between death and rebirth.

The Buddhist perspective emphasizes the impermanence of the body and the continuation of consciousness.

Christianity:

The phrase "passed away" reflects the belief in the soul moving from earthly life to an eternal realm. Christians often describe death as "going home" or "entering into rest," symbolizing a transition to heaven.

In Catholicism, there is also the concept of "passing through purgatory" for the purification of the soul before entering heaven.

Islam:

Death is viewed as a transition to the afterlife (Akhirah). The soul departs from the body and begins its journey through the grave and onto judgment day.

I understand Muslims often say, "To Allah we belong, and to Him we return" emphasizing the soul's return to its Creator.

African Traditional Beliefs:

Many African cultures view death as a passage to the spiritual world, where the deceased becomes an ancestor, maintaining a connection with the living.

Among the Yoruba of Nigeria, the phrase "God receives you" reflects the idea of the soul's transition.

Native American Beliefs:

Many Native American tribes view death as a continuation of the journey of the spirit. The body is seen as a temporary vessel, and the soul moves on to join ancestors or merge with the natural world.

The Lakota Sioux, for example, describe death as "crossing over" into the spirit world.

Jewish Beliefs:

While Judaism has diverse views on the afterlife, traditional texts often describe death as the soul returning to God. The phrase "gathered to his people" in the Torah signifies a transition to an ancestral or spiritual realm.

Secular/Philosophical Perspectives:

Even in non-religious contexts, phrases like "passing on" or "moving on" imply the continuity of some aspect of the self beyond physical death.

The commonality among these traditions is the deep-rooted belief that death is not an end but a passage or transformation, reflecting humanity's collective attempt to understand and give meaning to this universal experience.

Scientific Analogies:

The possibility of life's persistence across planetary systems supports the theories of panspermia (I shall write this separately) where life (or its precursors) could spread between worlds via comets or meteorites. While this doesn't directly address the "soul," it suggests a continuity of life on a cosmic scale.

Implications for the Nature of the Soul:

The idea that the breath of God is eternal and indestructible suggests to me that the soul transcends physical existence. This view implies that:

The physical body is a temporary vessel, housing the soul for a limited period.

After death, the soul transitions to another form or place, continuing its journey in the universe or beyond. This raises fascinating questions:

Does the soul retain individuality, memory, or consciousness as it transitions? My answer is a definite yes.

Could this cycle of life across worlds be part of a divine plan for growth, learning, or spiritual evolution?

A Unified Perspective:

This theory elegantly bridges science and faith. While science explores the physical origins and mechanisms of life, faith addresses the metaphysical and spiritual dimensions. Together, they provide a more holistic understanding of existence:

Science reveals how the elements of life were created and assembled.

Faith offers an answer to why these lifeless elements were animated and given purpose.

Closing Thoughts

I believe my thinking supports the view that life is a cosmic journey, transcending individual existence. It challenges us to see ourselves not just as beings tied to Earth but as participants in an eternal cycle spanning the cosmos.

It not only reconciles scientific knowledge with spiritual wisdom but also encourages reflection on the interconnectedness of life, matter, and the divine. This point of view  reminds us of our profound connection to both the universe and its Creator.

 

Thursday, December 26, 2024

The Importance of Giving Thanks to God Before a Meal

 

I have already written the  importance of us giving grace to God before each meal . It was written as far back as on Tuesday, August 5, 2014

https://scientificlogic.blogspot.com/2014/08/giving-grace-why-we-need-to-give-grace.html

Here’s a shorter and easier version for Christmas

Saying grace before meals is a time-honoured tradition that transcends cultures and religions, serving as a moment to express gratitude for the nourishment provided. This practice holds deep significance, both spiritually and communally.

Biblical Foundations

The act of giving thanks before meals is rooted in biblical tradition. Jesus Christ himself set a precedent by offering thanks before distributing food. In the miracle of feeding the five thousand, Jesus took the loaves and fish, gave thanks, and then distributed them to the people (Matthew 14:19). Similarly, at the Last Supper, He gave thanks before breaking bread with His disciples (Matthew 26:26-28). These instances highlight the importance of acknowledging God's provision.

Expression of Gratitude

Praying before meals is an opportunity to recognize and thank God for His provision. As stated in 1 Timothy 4:4-5, "For everything created by God is good, and nothing is to be rejected if it is received with thanksgiving, for it is made holy by the word of God and prayer." This act of gratitude transforms a routine meal into a moment of spiritual reflection, reminding us of our dependence on God's grace.

Desiring God

Mindful Consumption

In today's fast-paced world, it's easy to consume meals mindlessly. Pausing to say grace encourages mindfulness, allowing individuals to appreciate the food and the effort involved in its preparation. This moment of reflection can transform eating into an act of celebration and gratitude.

Oprah

Fostering Community and Connection

Saying grace is often a communal activity, bringing people together in a shared expression of thanks. This practice can strengthen bonds among family and friends, fostering a sense of unity and shared appreciation for the blessings received.

Spiritual Nourishment

Beyond physical sustenance, praying before meals serves as a reminder of spiritual nourishment. Jesus referred to Himself as the "Bread of Life," emphasizing the importance of seeking spiritual fulfilment alongside physical nourishment (John 6:35). By giving thanks, individuals acknowledge their reliance on God for both physical and spiritual sustenance.

The Rebelution

Conclusion

Incorporating the practice of saying grace before meals enriches the dining experience, transforming it into an opportunity for gratitude, mindfulness, and spiritual reflection. By acknowledging God's provision, we cultivate a heart of thankfulness and recognize the deeper significance of the nourishment we receive.


Wednesday, December 25, 2024

The Role of Allopurinol in Chronic Kidney Disease?

 

 Following an article “ Understanding Gout: A Multifaceted Condition” I penned today in the link below for Christmas, Professor Dr Vythilingam, a medical doctor friend of mine,  posed this question for me:

“Thank you very much Prof. This will be a good read for Christmas. I would like to request another article in your blog on the role of allopurinol medication in CKD with non-gout uricemia. I would appreciate that very much Sir. Thank you and have a wonderful day with family and friends”

 
https://scientificlogic.blogspot.com/2024/12/understanding-gout-multifaceted.html

 

First, I thank Professor Vythi, a vegan, for his very challenging Christmas question for me to field. Now I need to write, not one, but two Christmas articles today for Xmas. I don’t think I will be able to have a wonderful day with family and friends for Christmas having to deal with two articles today. Anyway, I like academic challenges come what may even if I need to cross hostile territories with gun fires at my defenceless self.   

 

Understanding the Mode of Action of Allopurinol:

 

First of all, before I answer Professor Vythi, let me explain the pharmacodynamic how allopurinol works. Allopurinol is a purine analogue that has been first line treatment for gout since the 1960s As far as my knowledge on medicine and pharmacology allows me, when allopurinol is given to a patient with elevated uric acid (uricemia or even hyperuricemia),  it is metabolized in the liver to its active metabolite, oxypurinol (alloxanthine) via endogenous pathways that normally function for the purines, hypoxanthine and xanthine.

 In the human liver this reaction is primarily carried out by aldehyde oxidase (AOX1).  Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid.

In short, allopurinol is used in the management of elevated uric acid that causes gout. However, Professor Dr Vythilingam asked me the role of allopurinol in CKD (chronic kidney disease) with no gout uricemia?

Let me try to handle this very challenging question because in CKD, it is not just hyperuricemia but uraemia, a general buildup of all waste products that normally can only be treated with haemodialysis

To answer the specific question regarding its role in chronic kidney disease without gout or uricemia, let me try to explain  this  topic systematically.

The use of allopurinol in CKD patients who do not have gout-related hyperuricemia has been a subject of investigation. While uraemia in CKD involves the accumulation of various toxins due to impaired renal clearance, uric acid plays a unique and potentially harmful role, even in the absence of gout symptoms.

Firstly, we need to examine the role of uric acid in CKD progression. Although not all CKD patients have hyperuricemia, elevated uric acid levels—even within the "high-normal range"—may contribute to:

First, on renal vascular dysfunction.  Uric acid promotes endothelial dysfunction, oxidative stress, and inflammation, worsening renal perfusion.

Second, on renal interstitial damage.  Uric acid crystals or related inflammatory responses can damage tubular cells, accelerating kidney damage.

Third, hypertension and cardiovascular complications.  Uric acid may activate the renin-angiotensin-aldosterone system (RAAS), contributing to high blood pressure and cardiovascular strain.

For these reasons, uric acid is considered a modifiable factor in CKD progression.

Our question is, what would be allopurinol’s potential benefits in CKD?

The first answer I can give is, the  reduction of oxidative stress and inflammation. By this, I mean by inhibiting xanthine oxidase, allopurinol reduces the production of reactive oxygen species (ROS), which are generated during uric acid formation. This mitigates oxidative damage in CKD.

My second answer is, the  slowing of CKD progression.  Some studies (e.g., the CKD-FIX trial and earlier observational studies) suggest that allopurinol might slow the decline in glomerular filtration rate (GFR) by reducing uric acid-associated damage, even in patients with normal serum uric acid levels.

My Third answer is, there may be an improvement in cardiovascular outcomes since CKD patients are at high risk of cardiovascular complications, reducing oxidative stress and endothelial dysfunction with allopurinol may offer additional benefits.

There is clinical evidence supporting my answers using allopurinol in CKD. For example, studies by Goicoechea et al., in 2010 have shown positive outcomes where a randomized controlled trial showed that CKD patients treated with allopurinol had slower GFR decline and fewer cardiovascular events than controls, even when uric acid levels were not markedly elevated. Furthermore, there was a reduction in proteinuria.  Allopurinol has been associated with reduced proteinuria, a marker of kidney damage.

However, there are also studies with mixed results. For example, in the CKD-FIX trial (2020), a larger and more rigorous study, found no significant difference in GFR decline between allopurinol and placebo in CKD patients. However, allopurinol was well-tolerated, and secondary benefits (e.g., cardiovascular effects) were not fully explored.

Nevertheless, I need to provide caution with allopurinol in CKD.

First, dosage adjustment is required. Allopurinol and its metabolite, oxypurinol, are excreted renally, so dosing must be adjusted to avoid accumulation and toxicity in CKD patients.

Then we need to look at the risk of hypersensitivity reactions.  Patients with advanced CKD are at higher risk of allopurinol hypersensitivity syndrome (AHS), a rare but severe reaction.

But all is not lost. There is an alternative to allopurinol, and that is - Febuxostat

In patients with CKD, febuxostat, a non-purine xanthine oxidase inhibitor, may be an alternative. It is primarily metabolized in the liver and less dependent on renal excretion, potentially reducing toxicity in CKD patients. However, its cardiovascular safety profile remains a concern.

My concluding  answer to Professor Vythi's very difficult question is,  the role of allopurinol in CKD without gout-related hyperuricemia lies in its potential to slow CKD progression and reduce oxidative stress and inflammation. However, the evidence is mixed, and its routine use in this context is not yet universally endorsed. Clinical judgment, careful patient selection, and close monitoring are essential, especially considering the risk of toxicity in advanced CKD.

Allopurinol might be beneficial in specific CKD patients with borderline uric acid levels, inflammation, or high cardiovascular risk, but it is not a substitute for haemodialysis in managing uraemia. Its use should be considered as part of a multifactorial approach to managing CKD.

I hope my explanation provides clarity and satisfies your curiosity Professor. Wishing you a joyful and peaceful 2024 Christmas Professor Dr Vythilingam.

No more questions  from anyone for now as I have been searching for the literature and have been typing out my answers all day through this “blessed” Christmas Day since Christmas Eve last evening .

I need dinner now to survive.

Warm regards,

ju-boo lim

8:38 pm Malaysian Time

25 December 2024. 

Tuesday, December 24, 2024

Understanding Gout: A Multifaceted Condition

  

Understanding Gout: A Multifaceted Condition


by:  ju-boo lim


Before I write, let me wish all readers a very blessed Christmas today, and a bountiful New Year 2025 ahead.   

Christmas Day on 25 December is just an arbitrary date for the birth of Jesus. The exact date of His birth is not known. See explanation on the Birth Star of Jesus here:

The Mystery of The Star in the East

https://scientificlogic.blogspot.com/search?q=star+in+the+east

On this note, I also like to wish my first-born son Benjamin Lim Chong Minn a very Blessed Birthday. He was born on Christmas Eve under an exceptionally clear sky with Orion overhead and the Morning Star Venus rising in the East. I took note of this as astronomy is one of my fields of interest where I have some formal training.

This article on gout was written in July 1999 as a concise lecture note given out during a lecture for doctors delivered by me. It was never meant for this blog. However, at a request of a doctor friend of mine who recently asked me a question of uric acid, I decided to have this article posted here for interested readers as well.

Let’s now go into uric acid and gout.


A 45-year-old male patient who was a vegetarian once came to consult me about his gout that kept occurring despite seeking repeated treatment elsewhere. He was puzzled how he could develop gout when he hardly consumed meat.


Let me straight away clarify this.  It is not necessary to be a meat eater to suffer from gout. Neither is it true that vegans and vegetarians are immune to gout.
This condition arises from elevated levels of uric acid in the body. Unlike urea, which is highly soluble in water and easily excreted through the kidneys, uric acid is only sparingly soluble. When its levels rise beyond the body's capacity to excrete it, uric acid can crystallize in the blood, kidneys, and particularly in the joints. This results in inflammatory arthritis that manifests in painful flares.


Gout is historically known as the "disease of kings" It was once associated with the wealthy due to their access to rich diets. Today, it serves as a reminder that both dietary and metabolic factors contribute to its development.


Gout is a complex form of inflammatory arthritis characterized by sudden, severe attacks of pain, redness, and tenderness in joints, often the joint at the base of the big toe. It results from elevated levels of uric acid in the blood, leading to the formation of urate crystals in joints. While traditionally associated with a diet rich in meat and alcohol, gout can also affect vegetarians, vegans and individuals with various dietary habits.


Understanding Uric Acid and Purines:

Uric acid is a waste product formed from the breakdown of purines, substances found naturally in the body and in certain foods. Normally, uric acid dissolves in the blood and passes through the kidneys into the urine. However, if the body produces too much uric acid or the kidneys excrete too little, uric acid can accumulate, forming sharp, needle-like urate crystals in a joint or surrounding tissue, causing pain and inflammation.


Dietary Considerations:

Meat and seafood like salmon, trout, and tuna can increase uric acid levels. However, their heart benefits may outweigh the gout risk.  Shellfish like crab, lobster, oysters, and shrimp too is high in purines. So are anchovies (ikan bilis), sardines, mackerel, herring, scallops. These seafoods have higher levels of purines than other types. However, this does not mean they cause gout when consumed occasionally in small amounts.

Purine-Rich Vegetable Foods:

Some vegetables, despite their health benefits, are high in purines. These include, asparagus, cauliflower, dried lentils, beans, and peas, green peas, mushrooms, spinach, whole grains like oats and wheat bran. Certain vegetables like asparagus, cauliflower, spinach, and mushrooms also contain significant purine levels. However, studies suggest that these vegetable sources do not increase the risk of gout and can be included in a balanced diet. Conversely, alcohol (especially beer) and beverages sweetened with high-fructose corn syrup can raise uric acid levels and should be limited. These foods should be eaten in moderation. 


However, studies suggest that these vegetable sources do not increase the risk of gout and can be included in a balanced diet. Conversely, alcohol (especially beer) and beverages sweetened with high-fructose corn syrup can raise uric acid levels and should be limited. These foods should be eaten in moderation.


On the other hand, purine-rich meats like anchovies, bacon, organ meats, red meats, sardines, scallops, and tuna need to be curtailed for individuals with gout. A diet emphasizing vegetables low in purines and incorporating low-fat or non-fat dairy products is often advised to help manage uric acid levels.

Sources of Uric Acid:


According to the Arthritis Foundation, approximately two-thirds of uric acid is produced endogenously as a by product of cellular metabolism, while the remaining one-third comes from dietary sources. Uric acid is formed during the breakdown of purines—compounds found in certain foods. While it is widely known that purine-rich meats contribute to gout, it is less well-known that certain vegetables and grains can also significantly increase purine intake.

Role of Salicylic Acid:


A lesser-known contributor to gout is salicylic acid (aspirin) found naturally in fruits and vegetables as a protective compound against diseases and pests. Studies have shown that salicylic acid can reduce the excretion of uric acid by the kidneys, exacerbating hyperuricemia. Vegetables particularly rich in salicylic acid include, broccoli, cauliflower, mushrooms, cucumber, eggplant (brinjal), okra (lady’s fingers), peppers, radishes, spinach, squash and zucchini
The dual challenge of certain vegetables being high in both purines and salicylates highlights the complexity of dietary management in gout.
There are also other risk factors beyond diet. Other factors that contribute to the development of gout are:


1. Genetics: Family history can predispose individuals to gout.

2. Age and Gender: Men aged 30 to 50 are more susceptible, though postmenopausal women also face increased risk.

3. Obesity: Excess body weight increases uric acid production and reduces its excretion.

4. Kidney Function: Impaired renal function diminishes the body’s ability to excrete uric acid.

5. Medications: Certain medications, such as low-dose aspirin and diuretics, can increase uric acid levels.

Hydration and Lifestyle Modifications:


Adequate hydration helps maintain urine flow and reduces the risk of uric acid crystal formation. A daily water intake of at least 2 to 3 litres is recommended, unless contraindicated by other health conditions. Gradual weight loss, regular physical activity, and stress management techniques like yoga or meditation can also help manage gout.

Pathophysiology and Diagnosis:


Gout is diagnosed based on clinical criteria, including the identification of monosodium urate crystals in synovial fluid of the affected joint. This condition is characterized by painful joint inflammation, most commonly in the first metatarsophalangeal joint.

Clinical Manifestations of Gout:


When uric acid or its salts (monosodium urate) accumulate and crystallize in the joints, they trigger intense pain and inflammation known as a gout attack. The condition typically affects the first metatarsophalangeal joint (the base of the big toe), although other joints may also be involved.
The diagnosis of gout is usually based on clinical criteria from the American College of Rheumatology. It can be confirmed by identifying monosodium urate crystals in synovial fluid aspirated from the affected joint.

Management and Prevention:


Acute gout attacks may be treated with nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or colchicine. To reduce the likelihood of recurrent flares, patients should limit their consumption of purine-rich foods and avoid alcoholic drinks and beverages sweetened with high-fructose corn syrup. Medications like allopurinol and febuxostat are first-line options for preventing recurrent gout, while colchicine and probenecid are reserved for patients who cannot tolerate first-line agents.


To prevent recurrences, patients are advised to:


1. Limit purine-rich foods (e.g., organ meats, shellfish)


2. Avoid alcohol, especially beer


3. Avoid beverages sweetened with high-fructose corn syrup


4. Maintain adequate hydration to promote uric acid excretion


Certain medications also play a role. For example:


1. Low-dose aspirin (commonly used for cardiovascular protection) can reduce uric acid excretion and contribute to hyperuricemia.


2. Loop and thiazide diuretics can increase uric acid levels.


3. Losartan, an angiotensin receptor blocker, enhances uric acid excretion and may be beneficial for patients with gout.


Long-term management involves reducing uric acid levels using medications like allopurinol or febuxostat. For patients who are intolerant to these drugs, colchicine or probenecid may be used. Uric acid levels should be reduced to target levels (below 6 mg/dL) and maintained for at least three months in patients without tophi or six months in those with a history of tophi.

Emerging Treatments and Research:


Recent studies have explored biological therapies, such as pegloticase, for severe or refractory cases of gout. Additionally, research into the gut microbiome's role in uric acid metabolism may open new avenues for treatment. Natural supplements like cherry extract or vitamin C are also being studied for their potential to lower uric acid levels.

Gout and Comorbidities:


Gout often coexists with other conditions, including hypertension, obesity, dyslipidemia, type 2 diabetes mellitus, hypertension, and chronic kidney disease. This underscores the importance of comprehensive health management in patients with gout. It is a multifactorial condition influenced by diet, genetics, and lifestyle. A comprehensive management strategy that includes dietary modifications, lifestyle changes, and appropriate medical treatment can help control and prevent gout flares.


This underscores the importance of adopting a holistic approach to managing gout, emphasizing proper nutrition, medication adherence, and addressing underlying comorbidities.


Gout serves as a reminder of how interconnected our diet, metabolism, and health truly are. While it is traditionally associated with meat consumption, gout can affect vegetarians and omnivores alike. A careful balance of nutrition, lifestyle modifications, and medical management is key to controlling this complex condition.

Risk Factors Beyond Diet:


Although diet plays a significant role in gout, it is not the sole factor. Other risk factors include, genetics and  family history of gout can predispose individuals to the condition. Men are more likely to develop gout, especially between the ages of 30 and 50, although postmenopausal women also face increased risk. Excess body weight increases uric acid production and reduces its excretion. Impaired renal function diminishes the body's ability to excrete the uric acid.
In addition to dietary adjustments, certain lifestyle changes can significantly reduce the risk and severity of gout flares:


Weight management to gradually reduce uric acid levels without triggering a flare. Rapid weight loss, however, should be avoided as it can increase uric acid temporarily. Regular physical activity helps improve overall metabolic health and reduces comorbid conditions like obesity and hypertension.
Chronic stress can increase inflammation and worsen gout symptoms. Relaxation techniques such as yoga, meditation or other stress management may be beneficial.
 

Hydration and Its Role in Uric Acid Excretion:


Emphasizing the importance of hydration could be useful. Drinking sufficient water helps maintain urine flow and reduces the risk of uric acid crystal formation in the kidneys and joints. Recommending a daily water intake of at least 2 to 3 litres, unless contraindicated by other health conditions, can reinforce this point.

Emerging Treatments and Research:


Discussing emerging therapies or ongoing research into gout management could be insightful. For example:

Biological Therapies:


Medications like pegloticase, an enzyme that breaks down uric acid, are used in severe or refractory cases of gout. Studies suggest that the gut microbiome may play a role in uric acid metabolism, opening new avenues for treatment.  Natural supplements like cherry extract or vitamin C are being studied for their potential to lower uric acid levels.
Preventing gout in individuals at risk could be another valuable addition. Preventive measures might include routine  monitoring uric acid levels in individuals with risk factors.


Prophylactic medications may be considered in certain high-risk patients, starting medications like allopurinol even before the onset of symptoms.


Conclusion:

Gout is one of the lifestyle diseases. As such, it must be managed holistically by considering all the causative factors already explained, and not merely treat it with colchicine or allopurinol.


References:
 

General Overview and Pathophysiology:


1. Richette, P., & Bardin, T. (2010). Gout. The Lancet, 375(9711), 318-328.
This article provides a comprehensive review of the pathophysiology, diagnosis, and management of gout, including the role of uric acid in the disease process.

2. Dalbeth, N., & Stamp, L. K. (2014). Gout: Pathophysiology and management. Nature Reviews Rheumatology, 10(12), 667-677.
A detailed review of gout's pathophysiology and the latest advances in its management

Diagnostic Criteria:


3. American College of Rheumatology. (2015). 2015 American College of Rheumatology/European League Against Rheumatism classification criteria for gout. Arthritis & Rheumatology, 67(5), 1307-1314.
This provides updated classification criteria for gout diagnosis, based on clinical and laboratory findings.

Management and Treatment:


4. Schlesinger, N., & Stojanovic, A. (2017). Acute gout: Diagnosis and management. Journal of Clinical Rheumatology, 23(6), 343-349.
This article reviews the diagnostic and treatment strategies for managing acute gout attacks.


5. Terkeltaub, R. A. (2003). Clinical practice. Gout. The New England Journal of Medicine, 349(17), 1647-1655.


A classic paper on the clinical management of gout, including both acute and chronic phases of the disease.
DOI: 10.1056/NEJMcp035643


6. Yang, T., & Li, W. (2020). Colchicine for the treatment of gout: A review of current evidence. American Journal of Therapeutics, 27(3), e253-e259.
A review of the evidence regarding the use of colchicine in managing acute gout.
DOI: 10.1097/MJT.0000000000000990

Dietary Considerations:


7. Choi, H. K., & Curhan, G. (2008). Beer, liquor, and wine consumption and risk of gout in men. The New England Journal of Medicine, 359(6), 585-591.


This study investigates the relationship between alcohol consumption and the risk of developing gout, providing important insights into dietary management.


8. Gaffo, A. L., & Saag, K. G. (2015). Management of gout: Current evidence and clinical guidelines. Current Rheumatology Reports, 17(7), 1-10.
A review on managing gout through both pharmacologic and lifestyle interventions, including diet.


These references cover the major aspects of gout, from pathophysiology to diagnosis, treatment, and lifestyle factors

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